Projects
Through out my M.Sc.-Ph.D. Carrier at IIT-Bombay (Mumbai, India), I have gone through the various projects according to courses need and by my interests. Few of them, I have listed below. For detailed knowledge & information feel free to contact me by visiting my contact page.
Newton-Bhabha Project:
Fabrication of Microneedles and modelling of Pumping system in Transdermal Theophylline Delivery
Our proposed product was potential to use current known standard chemistry measurement techniques to monitor the body fluids for theophylline levels and according to deliver the precise amount of drug in the body via Microneedle (MN) patch for treatment of asthma patients.
Different microneedle fabrication methods like bulk lithography and replica method with use of mold were performed with different materials. A different pumping system like peristaltic and micropump was modelled with use of some realistic data coming from literature and tested for its suitability in our proposed device.
Cancer Sensing Device Based On Impedance Measurement:
Cell-based biosensors provide new horizons for medical diagnostics by adopting complex recognition elements such as mammalian cells in microfluidic devices that are simple, cost efficient and disposable. This combination renders possible a new range of
applications in the fields of diagnostics and personalized medicine.
Hence I have made attempt to detect cancer cells from body fluid and also try to characterized types of cancer by observing I-V characteristics of each cancer cell lines output.
Cytoskeletal Dynamics in Growth Cone Motility and Axon Guidance:
Injury to the central nervous system (CNS) often results in permanent deficits because axons fail to undergo regeneration. The age dependent decline in intrinsic axon growth capacity make big obstacle in axons regeneration. Loss in axonal cells leads to communication and coordination gap among neuronal cells which impart deficits in functions.
Selective regulation of growth cone dynamics holds much promise as a novel strategy for promoting axon regeneration. Parameters of microtubule might be controlled by a network of microtubule-interacting molecules with distinct functions to specifically regulate different aspects of axonal growth. Microtubule-based approaches are emerging as attractive strategies owing to their potential to regulate multiple cellular activities.
Bioinfo. -Enzyme Degrading Central Metabolic Carbon Compound of Bacteria:
UniProt Database Results: PROTOCATECHUATE 3,4-DIOXYGENASE:- Having one α chain and one β chain. PROTOCATECHUAT 4,5-DIOXYGENASE :- Having one α chain and one β chain. PROTOCATECHUAT 2,3-DIOXYGENASE :- No information about its subunits and only one sequence is available.
Results: PC3,4-DO AND PC4,5-DO HAS SIGNIFICANT ROLE, HENCE CONSERVED THROUGH EVOLUTION. PC2,3-DO MEDIATES DIFFERENT PATHWAY OF DEGRADATION THEN THEIR COUNTRPARTS. PC2,3-DO MAY HAVE PHENOMENA OF TRAP AND ACT FASHION.
Isophthalate degradation by Acinetobacter lwoffii Strain ISP4:
Among all phthalate and their isomers, isophthalate is one of the foremost concerns due to reasons as described below Three phthalic acid isomers, ortho, meta, and para, may all be derived from the corresponding xylene isomers such as ortho, meta, and para respectively. The ortho-phthalic isomer has been produced from o-xylene and terephthalic acid is derivative of p-xylene. But isophthalic acid is produced from m-xylene which is the most abundant of the xylene isomers, consequently large supplies of isophthalic acid from this raw material easily done.